Exploration of local isolate of highly pathogenic avian influenza clade 2.3.2.1 as vaccine candidate to prevent mass outbreak in East Java
نویسندگان
چکیده
Highly Pathogenic Avian Influenza (HPAI) H5N1 is a major problem in poultry industry many countries. It became endemic disease Indonesia since 2003. Recently, research revealed that current circulate HPAI has switched from clades 2.1 to 2.3.2.1. To eradicate this disease, methods such as stamping out and quarantine seem not suitable applied one of main sector agricultural commodity some areas Central Java, Yogyakarta, East Java. provides large job opportunity for native people rural city areas. prevent the morbidity vaccination use local seed primarily needed. This was conducted explore isolate clade 2.3.2.1 vaccine candidate. Samples were obtained Java where outbreak occurred. Molecular characteristic according Neuraminidase (N) gene conducted. close relativity circulating virus used then processed into killed production. challenged observe protectivity on poultry. The effectivity measured through Haemagglutination Inhibition (HI) assay. result study showed DOD_3_2013 thus it Challenged test candidate induced higher antibody titer compared control. average 8.2 (log2) with protection level 100%. concluded could be around
منابع مشابه
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ژورنال
عنوان ژورنال: Iraqi journal of Veterinary Sciences
سال: 2021
ISSN: ['2071-1255', '1607-3894']
DOI: https://doi.org/10.33899/ijvs.2020.127331.1498